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DESIGN OF FAST DISSOLVING ORAL FILMS OF DOMPERIDONE USING SOLVENT CASTING TECHNIQUE

From the results it was observed that disintegration time of all the batches ranges between sec, tensile strength between 0. Thus, developed film can be useful for curing the emergency condition like schizophrenia which gives rapid relief within short time. Stability study was carried out for 3 months in final optimized formulation. QT has tendency of minimum extrapyramidal symptoms. Polyox N was selected for further optimization of film property due to its excellent film forming nature with optimum viscosity for rapid dissolving film. Experimental trials were performed at all 9 possible combinations with 5 replication batches.

Thus, it can be concluded that by adopting a systematic formulation approaches, an optimum point can be reached in the shortest time with minimum effort. International Journal of Pharmaceutics. Mendenhall W, Sincich T. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. A high and low dose double blind comparison with placebo. Other parameters remain unaltered after 3 months of storage.

Thus, it can be concluded that by adopting a systematic formulation approaches, an optimum point can be reached in the shortest time with minimum effort.

From the results it was observed that disintegration time of all the batches ranges between sec, tensile strength between 0.

For validation of optimum formulation, check usin R14 was prepared and evaluated for all the response.

Stability study data shows need of proper storage condition for film to protect from effect of moisture. Film was prepared by solvent casting method.

So, it was found that polyox was sensitive to moisture and humidity. Quetiapine In patients of Schizophrenia. Concentration of polymer and plasticizers were optimized by central composite design.

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Fast dissolving oral Domperidoone are the novel dosage forms that disintegrate and dissolve within the oral cavity within a minute, without needing water or chewing. Infrared analysis revealed no interaction between Domperidone and polymers.

Conclusion The results of central composite design revealed that the entire factor significantly influences the dependent variable. Glycerin and propylene glycol showed more sticky film which was unable to detach from surface. Archive Journal of Psychiatry. Open in a separate window. Ankit Chaudhary1 and A.

Sunita ChaudharyB. J Pharm Bioallied Sci. A novel approach to drug delivery, Drug Development Technology. Author information Copyright and License information Disclaimer.

Check point batch was compared for predicted value with observed value. Formulation F1 released A novel fast release oral film drug delivery system for the treatment of emesis in pediatrics and geriatric patients was developed for immediate oral delivery of Domperidone which is an excellent antiemetic drug.

Stability study was carried out for 3 months in final optimized formulation. Different grades of polyox were used for film formation like N10, N80, N and N Film texture was evaluated after 3 months of storage which indicates increase in stickiness of film at higher relative humidity. Poly ethylene glycol showed good film forming property with good flexibility. The prepared films were evaluated for their thickness uniformity, folding endurance, content uniformity, surface pH, In-vitro disintegration time and In-vitro drug release.

Domperidone films were prepared by solvent casting technique using two water soluble polymers, Pullulan and Sodium carboxy methyl cellulose in different concentration. The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however, patient compliance must not be overlooked.

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Formulation development and optimization of polyox based quick dissolving film of quetiapine

Other parameters remain unaltered after 3 months of storage. In this design 2 factors were evaluated, each at 3 levels. QT is rapidly absorbed and well tolerated drug. From concept to commercialization. Fast dissolving oral drug delivery systems, such as, fast dissolving oral films, offer a convenient way of dosing medications, not only to special population groups with swallowing difficulties such as pediatric and geriatric patients, but also to the general population.

Polyox N was selected for further optimization of film property due to its excellent film forming nature with optimum viscosity for rapid dissolving film.

Formulation development and optimization of polyox based quick dissolving film of quetiapine

Quetiapine QT is used to treat schizophrenia attack and bipolar disorder having half-life of 6 hours. Drug interaction was confirmed by FTIR spectra. After 3 months film was again evaluated for all parameters.

QDT is most successful dosage form in tablet but film possesses more benefits than tablet due to availability of larger surface area which leads to rapid disintegrating and thereby dissolution in the oral cavity. Dellen Publishing Co; Some predictable changes were observed in film property like decrease in disintegration time and more softness of film due to higher amount of moisture. Authors acknowledge the Institute of Pharmacy, Nirma university and Saraswati institute of pharmaceutical sciences, Dhanap, Gandhinagar for providing the research facilities.